Selasa, 21 Juni 2011

[T654.Ebook] Fee Download Genetic Mapping in Experimental Populations, by J. W. Van Ooijen, J. Jansen

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Genetic Mapping in Experimental Populations, by J. W. Van Ooijen, J. Jansen

Genetic Mapping in Experimental Populations, by J. W. Van Ooijen, J. Jansen



Genetic Mapping in Experimental Populations, by J. W. Van Ooijen, J. Jansen

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Genetic Mapping in Experimental Populations, by J. W. Van Ooijen, J. Jansen

Genetic linkage maps are an increasingly important tool in both fundamental and applied research, enabling the study and deployment of genes that determine important biological traits. This concise introduction to genetic mapping in species with disomic inheritance enables life science graduate students and researchers to use mapping software to produce more reliable results. After a brief refresher on meiosis and genetic recombination, the steps in the map construction procedure are described, with explanations of the computations involved. The emphasis throughout is on the practical application of the methods described; detailed mathematical formulae are avoided and exercises are included to help readers consolidate their understanding. A chapter on recognising and solving problems provides valuable guidance for dealing with real-life situations. An extensive chapter dedicated to the more complex situation of outbreeding species offers a unique insight into the approach required for many economically important and model species, both plants and animals.

  • Sales Rank: #2082397 in Books
  • Published on: 2013-09-23
  • Released on: 2013-08-08
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.72" h x .39" w x 6.85" l, .75 pounds
  • Binding: Paperback
  • 167 pages

About the Author
Dr J .W. (Johan) Van Ooijen has worked in the field of genetic linkage analysis for more than 20 years. He developed the QTL analysis software MapQTL� and was also involved in the development of JoinMap�, Piet Stam's genetic linkage mapping software. He continues the development of both software packages in his company, Kyazma B.V., and regularly teaches courses on genetic mapping and QTL analysis.

Dr J. (Hans) Jansen is a senior member of the Biometris group at Wageningen University and Research Centre. He is involved in research projects on various applications of molecular markers, including genetic diversity studies, the construction of genetic linkage maps, and QTL analysis involving multiple pedigree-related populations.

Most helpful customer reviews

0 of 0 people found the following review helpful.
Essential
By Ekrem Ayna
This is an essential source for gene mapping (linkage) with molecular genetic markers. It is not a reference but a collection of short course notes although comprehensive enough for two semesters of course.

The print has some quality issues (Again another valuable book printed on common photocopy paper) but no defaults. Just does not seems to endure for few years. Its is an essential text and could be and excellent teaching material.

0 of 0 people found the following review helpful.
A good buy
By Leonard
I bought this book from Amazon.com and I am happy I did because the had lots of information that I wanted

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Selasa, 14 Juni 2011

[K254.Ebook] Ebook If Our Bodies Could Talk: A Guide to Operating and Maintaining a Human Body, by James Hamblin

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If Our Bodies Could Talk: A Guide to Operating and Maintaining a Human Body, by James Hamblin

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If Our Bodies Could Talk: A Guide to Operating and Maintaining a Human Body, by James Hamblin

"If you want to understand the strange workings of the human body, and the future of medicine, you must read this illuminating, engaging book." —Siddhartha�Mukherjee,�author of�The Gene

In 2014, James Hamblin launched a series of videos for The Atlantic called "If Our Bodies Could Talk."� With it, the doctor-turned-journalist established himself as a seriously entertaining authority in the field of health. Now, in illuminating and genuinely funny prose, Hamblin explores the human stories behind health questions�that never seem to go away—and which tend to be mischaracterized and oversimplified by marketing and news media. �He covers topics such as sleep, aging, diet, and much more:

• Can I “boost” my immune system?
• Does caffeine make me live longer?
• Do we still not know if cell phones cause cancer?
• How much sleep do I actually need?
• Is there any harm in taking a multivitamin?
• Is life long enough?

In considering these questions, Hamblin draws from his own medical training as well from hundreds of interviews with distinguished scientists and medical practitioners.� He translates the (traditionally boring) textbook of human anatomy and physiology into accessible, engaging, socially contextualized, up-to-the-moment answers. They offer clarity, examine the limits of our certainty, and ultimately help readers worry less about things that don’t really matter.

If Our Bodies Could Talk is a comprehensive, illustrated guide that entertains and educates in equal doses.

  • Sales Rank: #15389 in Books
  • Published on: 2016-12-27
  • Released on: 2016-12-27
  • Original language: English
  • Number of items: 1
  • Dimensions: 8.50" h x 1.20" w x 6.10" l, 1.25 pounds
  • Binding: Hardcover
  • 400 pages

Review
“This book answers all the questions you ever had about your health—plus a whole lot of questions that never occurred to you but should have. Even if you don’t care about your health you should read it, because Hamblin is such a delightfully amusing writer.”
—Walter Isaacson, #1 New York Times bestselling author of The Innovators and Steve Jobs

"Reading James Hamblin’s book is like taking a journey through the vast and uncharted landscape of 'health science.'� Fad Diets. The science of vaccines. The truth (and lies) behind coffee. The rumblings of the stomach. If you want to understand the strange workings of the human body, and the future of medicine, you must read this illuminating, engaging book."
—Siddhartha Mukherjee, #1 New York Times bestselling author of The Gene and The Emperor of All Maladies

“Jim is the friendly pocket doctor I've always longed to carry around with me, chirping helpful medical advice into my ear like ‘You can't stop touching your face’ and alerting me to the dangers of ‘catching a wild cow and convincing it to let itself be milked.’ Without him, I might not have a body at all.”
—Mallory Ortberg, author of Texts From Jane Eyre

“[Hamblin] writes with sarcasm, humor, and a sense of astonishment…. He does a stellar job with nutrition, covering supplements, multivitamins, energy drinks, and gluten.� He calls out medical misinformation and marketing myths…. Educational, entertaining, and a bit eccentric.”
—Booklist�

“Fascinating... Challenging what one interviewee calls the ‘scientific misinformation and marketing-based “facts”’ we are bombarded with daily, this book will be a useful tool for helping people get in touch with their own bodies.”
—Publishers Weekly

“Charming, engrossing, occasionally heartbreaking, and at times political…�If Our Bodies Could Talk does not set out to be comprehensive, and yet it feels holistically so—a testament to Hamblin’s intelligence and humor.”
—Elle

“Underneath the curiosity factor and his nerdy charm, Hamblin conveys useful information. That’s a win-win for everyone.”
—Success.com�

“If Our Bodies Could Talk, they’d want James Hamblin taking dictation.”
—Sloane Crosley, Vanity Fair

"Witty"
—The New Yorker

"The book reads sort of like an FAQ section of a how-to manual for the human body, but it’s much more funny and engaging than any manual.”�
—The Daily Beast

"A�humorous, highly narrative, plainly written manual to the body that covers everything from why we scratch itches to how our hearts know to beat."�
—Missoula Independent

About the Author
JAMES HAMBLIN is a writer and senior editor at The Atlantic magazine. He was a 2015 Yale University Poynter Fellow in journalism, and his work has been featured by the New York Times, Politico, NPR, BBC, MSNBC, New York, and The Awl. He was a finalist for the 2015 Webby award for Best Web Personality, and Time has named him among the 140 people to follow on Twitter. He’s based in Brooklyn, New York.

Excerpt. � Reprinted by permission. All rights reserved.
PART ONE

APPEARING

THE SUPERFICIAL PARTS

Butterfly children” are so called because their skin is like butterfly’s wings. The name is meant to convey extreme fragility. But the weakness in butterfly wings is only a product of the fact that we are some one hundred thousand times larger than butterflies. In terms of biomechanics, these wings are actually paradigms of efficiency: light enough to be operated by a flying worm a fraction of their size, yet strong enough to hold up under the intense shear force of the wind and torrential rain that would be for us like standing under Niagara Falls.

The skin of a butterfly child, on the other hand, is rather an abject failure of biomechanics. Because of one detail. The formal name of the disease is dystrophic epidermolysis bullosa, or DEB. It’s traditionally considered a pathology of the skin, the domain of the dermatologist, because it renders the skin like tissue paper that has been left in the sun. Such skin falls apart at the lightest touch. The condition has no cure. It is the worst disease you’ve never heard of. I write that without presuming which diseases you have heard of. The trademarked motto of the Dystrophic Epidermolysis Bullosa Research Association is “the worst disease you’ve never heard of.” Its current executive director, Brett Kopelan, coined the phrase in earnest.

His daughter Rafi was born in a Manhattan hospital on November 19, 2007. Her mother, Jackie, was more than a little concerned that patches of skin were missing on their newborn’s hands and feet. She had been two weeks past due, and the doctors initially reassured Jackie and Brett that their baby had been “overcooked.” But the casual dismissal proved too casual when over the next few hours Rafi began bleeding. Nurses rushed her to the intensive care unit. There she would spend the first month of her life in complete isolation, undergoing a battery of tests, unable to be touched by her parents. After two weeks the doctors came to the Kopelans with a potential diagnosis, a name that would become their lives.

“They think it’s something called epi-�dermo-�lysis . . . ​bul�losa?” Brett recalls saying in a harried phone call with his brother, who is chief of surgery at a hospital just across the river in New Jersey, to which the surgeon replied, “Oh, shit.” Brett ran to Google and read about DEB. His first thought was that it was the worst disease he’d never heard of.

On the short arm of the third of your twenty-�three chromosomes sits a gene called COL7A1. It is responsible for the production of the protein that assembles collagen VII. Collagen proteins constitute all of the connective tissue in our bodies, and a third of our total protein. From the Greek for “glue,” collagen holds together everything from skin to ligaments and tendons. It comes in several known types (of which collagen VII is one).

Epidermolysis bullosa is a �rare disease in several ways, not least in that much of the problem traces to a discrete gene. Most diseases are far more complex than any single gene can explain. But mutations in the COL7A1 gene seem to be responsible for all three major forms of dystrophic epidermolysis bullosa, of which Rafi’s is the most severe.

Collagen VII anchors our outer layer of skin (epidermis) to our base layer (dermis). Without it, the layers separate and the skin crinkles and blisters, coming off at the slightest provocation. When Rafi reflexively scratches an itch, she wounds herself. The seams on her shirt cause blisters. Many mornings she wakes up with her pajamas pasted to her skin in multiple places by dried blood. The extrication is grueling.

And because collagen VII provides structure throughout the organs of her body, this affects not just the skin, but the internal organs as well. Blisters and scars within her mouth and esophagus make it difficult to chew and swallow food. She has eye inflammation that can lead to blindness. She has a very high risk of developing an aggressive type of skin cancer at a young age. She has osteoporosis, syndactyly (fusion of the fingers), and mild heart failure.

Rafi’s form of epidermolysis bullosa affects fewer than one in a million infants. For those who survive, life does not involve much interaction with other people. So it is a disease of people whom we are not likely to come to know. The spectrum of what most of us consider normal in our day-�to-�day lives is skewed strongly away from conditions like EB, and toward small blemishes. If it weren’t, we might be more appreciative of the skin that we have, and the simple fact that it adheres to our bodies.

The average person has about six pounds of skin. Like most (though not all) organs, it’s essential to life. If you woke up one day and your skin had vanished, you would quickly die. In what remained of your short life, there would be problems socially. It’s the largest and most dynamic organ in the human body, constantly turning over and regenerating. Skin, along with hair, is unique among body parts in that it is dead cells we carry around. In any other organ, dead cells are discarded. But the cells in skin and hair stay along with us for a while and serve important functions, not least of which is social identity and thus the foundation on which the understanding of ourselves is built.

The skin we had last year—�last season, even—�is not the skin we have today. Most of the cells that compose our bodies are constantly dying and being replaced. Around 8 percent of our genes are not even human, but viral. We are born with viruses woven into our DNA, and we contain trillions of bacteria that are responsible for, among other things, the appearances of our faces, our body weights, and our states of mind. Our bodies are dynamic networks of genetic information shaped by experience, and microbes that change who we are in every moment. We are born with signals that will tell us to go bald when most people would appraise us more favorably if we had hair, and to be anxious when we needn’t be, and to get cancers that we tried hard to avoid. The doling out of years and health and happiness will not be fair.

The seemingly superficial parts, and the way they are perceived by ourselves and others, accumulate into how we understand ourselves, and then into how we move through the world and treat one another.

How can I tell if I’m beautiful? I mean in the purely superficial physical way that I know I shouldn’t care about but do because I am a person who exists in the world.

In 1909, Maksymilian Faktorowicz opened a beautification establishment in Los Angeles. Under the name Max Factor, he would become famous for his cosmetic products, which he sold as part of a pseudoscientific process of “diagnosing” abnormalities in people’s (mostly women’s) faces. He did this using a device he invented called the “beauty micrometer.” An elaborate hood of metallic bands held in place by an array of adjustable screws, the micrometer could be placed over a woman’s head and, as one of his ads at the time claimed, flaws almost invisible to the ordinary eye would become obvious. Then he could apply one of his “makeup” products, a term coined by Factor, to correct the flaw in this person: “If, for instance, the subject’s nose is slightly crooked—�so slightly, in fact, that it escapes ordinary observation—�the flaw is promptly detected by the instrument, and corrective makeup is applied by an experienced operator.” Even if putting on a metal hood that could tell people exactly why they’re not beautiful didn’t seem wrong on infinite levels, there was also the problem that Factor’s micrometer was contingent on an empirical definition of beauty. A device that tells people what’s wrong with them is predicated on an understanding of what is right. Max Factor’s approach is a textbook example of the sales tactic that is still so successful in selling body-�improving products: convince people that there is a deficit in some concrete way, and then sell the antidote.

In the case of facial symmetry, some evolutionary biologists do believe that we are attracted to symmetric faces because they might indicate health and thus reproductive viability. From a strict perspective of evolutionary biology, someone with a prominent growth spiraling out of the side of their eye, for instance, might be viewed as a “maladaptive” choice for a mate. Instincts warn that this person may not survive through the gestation and child-�rearing process, possibly not even conception. Best to move on.

But today most people survive long enough to reproduce and care not just for children, but grandchildren, great-�grandchildren, and even domesticated cats. We can be less calculating about who to mate with. We can and do afford ourselves attraction not to some standard of normalcy, but to novelty and anomaly.

While Factor was convincing everyone that they were empirically inadequate based on a standard of normalcy that he created to sell products, the University of Michigan sociologist Charles Horton Cooley proposed a more nuanced approach, called “the looking glass self.” The idea was that we understand ourselves based not on some empirical idea of what is right or wrong about us, but from how others react to us. It’s difficult to believe you’re physically attractive when the world treats you otherwise, and vice versa. “The thing that moves us to pride or shame,” he wrote in 1922, “is not the mere mechanical reflection of ourselves, but an imputed sentiment, the imagined effect of this reflection upon another’s mind.”

Cooley repopularized the timeless idea that other people are not just part of our world, or even merely important to our understanding of ourselves: They are everything. Technically there are individual humans, just as technically coral is a collection of trillions of tiny sessile polyps, each as wide as the head of a pin. Alone in the sea, the polyps would be nothing. Together they are barrier reefs that sink ships.

The idea of a looking-�glass self could seem disempowering, in that our understandings of ourselves are subject to the perceptions of others. A less devastating way of thinking about a world of looking-�glass people, I think, is the idea that everywhere we go, not only are we surrounded by mirrors, but we are mirrors ourselves. It’s not the face in the Max Factor machine that matters, but the way that face is received. We can’t always choose our mirrors, but we can choose the kind of mirrors we will be—�a kind mirror, or a malevolent mirror, or anything in between.

Why do I have dimples?

The muscle that pulls the corners of your mouth up and back (a “smile”) is called the zygomaticus. In people with dimples, that muscle is shorter than in the average person and may be forked into two ends, one of which is tethered to the dermis of the cheek, which then gets sucked inward when the person smiles. This is one way that beauty happens.

It’s an anatomical anomaly, sometimes even referred to as a “defect.” That understanding comes from an oft-�cited theme in biology: that form necessarily correlates with function. Everything must happen for some reason, right? If dimples are a form without a clear function, then it’s easy to dismiss them as defects. It would be easier to write this book if it were the case that our body parts either had a clear purpose or else represented defects or diseases. But we’re more complex and interesting than that.

Biological function is a concept foundational to understanding health and disease, and it’s defined most often as the reason that a structure or process came to exist in a system. We have opposable thumbs, by the etiological theory of biological function, because they gave us an advantage in using certain tools.

While form can help inform our understanding of function, though, few cases are so clear-�cut as thumbs. Some beards grow, some skin peels, and some cheeks dimple because they evolved to do so in certain people under certain conditions. There is no “purpose,” teleologically, for beards to grow or skin to peel or cheeks to dimple.

Theoretically all functions should together contribute to our fitness—�to keeping us alive and well, as populations—�but they may not do so individually. In isolation, a particular bodily function—�like sleeping, for instance—�may seem to be only a weakness. Sleeping is a time when we might be eaten by birds. But it exists, according to leading theorists on the still outstanding question of why we sleep, because it augments the functions of other body parts.

Elements of our forms may also be vestigial, like wisdom teeth or appendices, relics that lost function over time as systems changed. There is a spectrum of vestigiality, with some parts trending toward obsolescence but not yet useless. Other parts may never have been functional, but simply emerged as side effects of the functions of other parts. (These are sometimes known as “spandrels,” an allusion to decorative flourishes in architecture that serve no purpose in supporting the structure.)

The overarching idea is that almost no body part can be explained in isolation. They make sense only in the context of whole people, just like whole people make sense only in the context of whole populations. In a parallel world, dimples are anomalies we would attempt to prevent or correct. But in this time and place we choose to desire and envy them. Sometimes even to create them by force.

If I didn’t have dimples, could I give them to myself?

In 1936, entrepreneur Isabella Gilbert of Rochester, New York, advertised a “dimple machine” that consisted of a “face-�fitting spring carrying two tiny knobs which press into the cheeks.” Over time, this force should produce “a fine set of dimples.”

It didn’t, though, because that is not how dimples work.

If only as an alternative to that particular form of hell, we may be fortunate that today a surgeon can perform a twenty-�minute procedure to suture a cheek muscle known as the buccinator to the interior surface of the skin of a person’s skin, creating a dimple. It can all be done without ever puncturing the skin from the outside, coming through the inside of the cheek and cutting out a little bit of the cheek muscle, then running a suture through that muscle to the undersurface of the skin in the cheek. Pull it tight, and the skin will pucker. This is all done while the person is awake.

The puckering is exactly the sort of outcome that cosmetic surgeons spend years perfecting the art of suturing in order to avoid. So it took a truly heterodox thinker to invent the procedure. Based in Beverly Hills, plastic surgeon Gal Aharonov considers himself the father of the American trend in dimple surgeries. “It wasn’t a trend before I started doing it,” he told me. That’s a phrase I rarely trust, but he does appear to have created the dimpling technique, about ten years ago.

Most helpful customer reviews

7 of 7 people found the following review helpful.
Funny and factual--this book proves you can have your cake and eat it too
By Jane Hamblin
I love the videos called If Our Bodies Could Talk (especially the one about red wine being good for me), so when I saw the same guy had written a book, I had to check it out. I began laughing and, yes, learning, four sentences in. His stuff is down to earth and helpful. You can skip around to read topics that interest you. Even the things I was less interested in were just as good and made a lot of sense--and were funny. No charlatan, the author is a credit to medicine and print media. I bought five books just now for friends.

4 of 4 people found the following review helpful.
Research is shared in a humorous and easy to understand script
By Mary Kay Morrison
Hamblin has written a captivating book that answers every health care question imaginable. His format includes asking copious questions and exploring the answers through real life stories of people who have experienced a variety of health conditions. Research is shared in a humorous and easy to understand script. An example of this format includes my favorite story in the book. It is in response to the question; “Am I having a seizure?” As a child, Beth Usher had so many seizures a day that her parents finally made the incredibly difficult decision to have half of her brain removed. Her inspiring journey includes the use of humor in the recovery process. Although Beth still has some disabilities as a result of the surgery, she completed the AATH (Association for Applied and Therapeutic Humor) Humor Academy program to become a CHP (Certified Humor Professional). Beth currently is a speaker presenting workshops titled “Always in My Right Mind”. Hamblin follows up on her story by exploring the research on topic rarely addressed in medical journals: “How is Laughter Medicine?” This book has my highest recommendation.

3 of 3 people found the following review helpful.
Fave book of 2017? I think so
By Jen Smith
Short review: Get this book. You'll not only laugh, but will learn a thing or two.

Long review: If Our Bodies Could Talk is a book that everyone will enjoy - from those that may have random bodily questions that they were too embarrassed to ask Google, to those that have backgrounds in Science and Medicine (and anywhere in between.) Worried about that contact being stuck in your brain? This will help. It's broken down into categories that allow the reader to skip around if you so wish, (although I recommend reading it from start to finish.) This is one of the few books that I've read in a little less than four days and laughed throughout. Jim manages to cover vast topics, from juice diets and fad eating, to everything in between without bias. It's a breath of fresh air to read a book that covers health, yet isn't trying to sell you on some weird supplements or products. If you enjoy reading Jim's Atlantic columns, or watching the video series If Our Bodies Could Talk, this will be right up your alley.

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If Our Bodies Could Talk: A Guide to Operating and Maintaining a Human Body, by James Hamblin PDF
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Jumat, 03 Juni 2011

[C841.Ebook] Free PDF A Collection of Design Pattern Interview Questions Solved in C++ (Volume 4), by Dr Antonio Gulli

Free PDF A Collection of Design Pattern Interview Questions Solved in C++ (Volume 4), by Dr Antonio Gulli

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A Collection of Design Pattern Interview Questions Solved in C++ (Volume 4), by Dr Antonio Gulli

A Collection of Design Pattern Interview Questions Solved in C++ (Volume 4), by Dr Antonio Gulli



A Collection of Design Pattern Interview Questions Solved in C++ (Volume 4), by Dr Antonio Gulli

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A Collection of Design Pattern Interview Questions Solved in C++ (Volume 4), by Dr Antonio Gulli

A collection of Design Patterns implemented in C++

  • Sales Rank: #1921488 in Books
  • Published on: 2014-05-21
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.00" h x .13" w x 6.00" l, .21 pounds
  • Binding: Paperback
  • 52 pages

Most helpful customer reviews

0 of 0 people found the following review helpful.
Great Reference book!
By Cayce Hrivnak
Before now, I was not really familiar with C++ or the different patterns used. This book actually lays out different types of design patterns, how to implement them, includes great examples on how to use them, and much more. It is laid out in a way you will understand and will help you with different questions you might have had about the different patterns.

Take a look at it! It may help you out!

0 of 0 people found the following review helpful.
Incorrect examples
By Amazon Customer
The first pattern in the book is the Abstract Factory pattern. Instead of giving an example of this, he instead shows an example of abstract inheritance. If someone were to use the author's example in an interview, the job would certainly be lost.

0 of 0 people found the following review helpful.
Great book!
By WDP
Excellent book! It's full of very useful and practical information.

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Kamis, 02 Juni 2011

[A499.Ebook] Ebook Thermodynamic Optimization of Complex Energy Systems (Nato Science Partnership Subseries: 3)From Springer

Ebook Thermodynamic Optimization of Complex Energy Systems (Nato Science Partnership Subseries: 3)From Springer

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Thermodynamic Optimization of Complex Energy Systems (Nato Science Partnership Subseries: 3)From Springer

Thermodynamic Optimization of Complex Energy Systems (Nato Science Partnership Subseries: 3)From Springer



Thermodynamic Optimization of Complex Energy Systems (Nato Science Partnership Subseries: 3)From Springer

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Thermodynamic Optimization of Complex Energy Systems (Nato Science Partnership Subseries: 3)From Springer

A comprehensive assessment of the methodologies of thermodynamic optimization, exergy analysis and thermoeconomics, and their application to the design of efficient and environmentally sound energy systems. The chapters are organized in a sequence that begins with pure thermodynamics and progresses towards the blending of thermodynamics with other disciplines, such as heat transfer and cost accounting. Three methods of analysis stand out: entropy generation minimization, exergy (or availability) analysis, and thermoeconomics.
The book reviews current directions in a field that is both extremely important and intellectually alive. Additionally, new directions for research on thermodynamics and optimization are revealed.

  • Sales Rank: #2654056 in Books
  • Published on: 2008-05-27
  • Original language: English
  • Number of items: 1
  • Dimensions: 9.17" h x 1.09" w x 6.10" l, 1.48 pounds
  • Binding: Paperback
  • 465 pages

Most helpful customer reviews

0 of 0 people found the following review helpful.
thermodynamic tools for optimization
By Joao Batista Campos Silva
The book is a compilation of several topics in Thermodynamics: entropy, exergy, complex systems such as cycles for energy conversion and refrigeration cycles. Many specialist authors wrote the chapiters of the book on concepts of the Thermodynamics. Concepts such as entropy and exergy are used for optimization of complex systems. The constructal theory is also used in optimization of systems. In this way, the book is an important reference for researchers and engineers to optimize the design of energy systems.

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